Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease-Reference-Cited by-同舟云学术

Stereoselective Synthesis of C-2 Alkylated Trihydroxypiperidines: Novel Pharmacological Chaperones for Gaucher Disease

Published:2019-02-08 Issue:4 Volume:10 Page:621-626
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Clemente Francesca¹^ORCID,Matassini Camilla¹²^ORCID,Goti Andrea¹²³^ORCID,Morrone Amelia⁴,Paoli Paolo⁵^ORCID,Cardona Francesca¹²³^ORCID

Affiliation:

1. Department of Chemistry “Ugo Schiff”, University of Firenze, via della Lastruccia n. 3-13, 50019 Sesto Fiorentino (FI), Italy

2. CNR-INO and LENS, Via N. Carrara 1, 50019 Sesto Fiorentino (FI), Italy

3. Consorzio Interuniversitario Nazionale di ricerca in Metodologie e Processi Innovativi di Sintesi (CINMPIS), 70125 Bari, Italy

4. Paediatric Neurology Unit and Laboratories, Neuroscience Department, Meyer Children’s Hospital, and Department of Neurosciences, Pharmacology and Child Health, University of Florence, Viale Pieraccini n. 24, 50139 Firenze, Italy

5. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Morgagni n. 50, 50134 Florence, Italy

Funder

Ministero dell?Istruzione, dell?Universit? e della Ricerca

Fondazione Cassa di Risparmio di Pistoia e Pescia

Universit? degli Studi di Firenze

Associazione Malattie Metaboliche Congenite

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00602

Reference27 articles.

1. Gaucher Disease: Basic and Clinical Perspectives

2. Phenotype, diagnosis, and treatment of Gaucher's disease

3. Safety, efficacy, and authorization of eliglustat as a first-line therapy in Gaucher disease type 1

4. Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones

5. Pharmacological Chaperones as Therapeutics for Lysosomal Storage Diseases

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