Structure–Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors-Reference-Cited by-同舟云学术

Structure–Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors

Published:2017-10-02 Issue:11 Volume:8 Page:1183-1187
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Sonawane Yogesh A.^ORCID,Zhu Yingmin¹,Garrison Jered C.^ORCID,Ezell Edward L.,Zahid Muhammad,Cheng Xiaodong¹,Natarajan Amarnath^ORCID

Affiliation:

1. Department of Integrative Biology and Pharmacology and Texas Therapeutics Institute, University of Texas Health Science Center, Houston, Texas 77030, United States

Funder

U.S. Department of Health and Human Services

Eppley Foundation for Research

Fred and Pamela Buffett Cancer Center

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00358

Reference26 articles.

1. Advances in the Chemistry of Tetrahydroquinolines

2. Identification of a Tetrahydroquinoline Analog as a Pharmacological Inhibitor of the cAMP-binding Protein Epac

3. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1)

4. Lezoualc’h, F.; Fischmeister, R.; Bisserier, M.; Bouyssou, P.; Blondeau, J. P.; Courilleau, D. Tetrahydroquinoline Derivatives and Their Use as EPAC Inhibitors. US 20150252002A1, 2015.

5. A Fluorescence-Based High-Throughput Assay for the Discovery of Exchange Protein Directly Activated by Cyclic AMP (EPAC) Antagonists

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