Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer-Reference-Cited by-同舟云学术

Tetrahydroquinoline: an efficient scaffold as mTOR inhibitor for the treatment of lung cancer

Published:2022-12 Issue:23 Volume:14 Page:1789-1809
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Chaube Udit¹^ORCID,Dey Rajdeep¹^ORCID,Shaw Suman¹^ORCID,Patel Bhumika D¹^ORCID,Bhatt Hardik G¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382481, India

Abstract

Efforts have been made to find an efficient scaffold (and its substitution) that can be used for the treatment of lung cancer via mTOR inhibition. A detailed literature search was carried out for previously reported mTOR inhibitors. The present review is focused on lung cancer; therefore, descriptions of some mTOR inhibitors that are currently in clinical trials for the treatment of lung cancer are provided. Based on previous research findings, tetrahydroquinoline was found to be the most efficient scaffold to be explored for the treatment of lung cancer. A possible efficient substitution of the tetrahydroquinoline scaffold could also be beneficial for the treatment of lung cancer.

Funder

Nirma University

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2022-0204

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