Consequences of Depsipeptide Substitution on the ClpP Activation Activity of Antibacterial Acyldepsipeptides
Author:
Affiliation:
1. Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, United States
Funder
University of Oklahoma
Oklahoma Center for the Advancement of Science and Technology
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00320
Reference32 articles.
1. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
2. Bacterial caseinolytic proteases as novel targets for antibacterial treatment
3. Activated ClpP kills persisters and eradicates a chronic biofilm infection
4. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
5. Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP
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