Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

Author:

Li Dominic Him Shun,Chung Yu Seon,Gloyd Melanie,Joseph Ebenezer,Ghirlando Rodolfo,Wright Gerard D.,Cheng Yi-Qiang,Maurizi Michael R.,Guarné Alba,Ortega Joaquin

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference48 articles.

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3. The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexes;Bewley;J. Struct. Biol.,2006

4. Turned on for degradation: ATPase-independent degradation by ClpP;Bewley;J. Struct. Biol.,2009

5. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics;Brotz-Oesterhelt;Nat. Med.,2005

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