Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity-Reference-Cited by-同舟云学术

Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity

Published:2017-07-31 Issue:8 Volume:8 Page:875-880
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Yang Chengbin¹,Zhang Xi²,Wang Yi²,Yang Yongtai¹,Liu Xiaofeng¹,Deng Mingli¹,Jia Yu¹,Ling Yun¹^ORCID,Meng Ling-hua²,Zhou Yaming¹^ORCID

Affiliation:

1. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Department of Chemistry, Fudan University, Shanghai 200433, China

2. Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Funder

Shanghai Municipal Education Commission

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00222

Reference30 articles.

1. PI3K and cancer: lessons, challenges and opportunities

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3. Phosphoinositide 3-Kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis

4. Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

5. Targeting the phosphoinositide 3-kinase pathway in cancer

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