Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach-Reference-Cited by-同舟云学术

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Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach

Published:2023-10-03 Issue:11-12 Volume:23 Page:364-376
ISSN:1530-7905
Container-title:Cardiovascular Toxicology
language:en
Short-container-title:Cardiovasc Toxicol

Author:

Wu Tianze,Chen Yi,Yang Chengbin,Lu Mingzhu,Geng Fang,Guo Jianhua,Pi Yan,Ling Yun,Xu Jun,Cai Tong,Lu Lei,Zhou Yaming

Funder

National Natural Science Foundation of China

International Science & Technology Innovation Collaboration Project of Shanghai

the Commission for Science and Technology of Shanghai

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine,Toxicology,Molecular Biology

Link

https://link.springer.com/content/pdf/10.1007/s12012-023-09809-2.pdf

Reference52 articles.

1. Li, C., Zou, R., Zhang, H., Wang, Y., Qiu, B., Qiu, S., Wang, W., & Xu, Y. (2019). Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo. Archives of Toxicology, 93(6), 1697–1712.

2. Zhao, W. N., Qiu, Y. L., & Kong, D. X. (2017). Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy. Acta Pharmaceutica Sinica B, 7(1), 27–37.

3. Chen, Y., Wu, T. Z., Yang, C. B., Lu, M. Z., Chen, Z. X., Deng, M. L., Jia, Y., Yang, Y. T., Liu, X. F., Wang, H. Y., Ling, Y., Lu, L., & Zhou, Y. M. (2022). A pyridinesulfonamide derivative FD268 suppresses cell proliferation and induces apoptosis via inhibiting PI3K pathway in acute myeloid leukemia. PLoS ONE, 17(11), e0277893.

4. Yang, C., Gong, Y., Gao, Y., Deng, M., Liu, X., Yang, Y., Ling, Y., Jia, Y., & Zhou, Y. (2023). Design, synthesis and in vitro biological evaluation of 2-aminopyridine derivatives as novel PI3Kdelta inhibitors for hematological cancer. Bioorganic & Medicinal Chemistry Letters, 82, 129152.

5. Durrant, T. N., & Hers, I. (2020). PI3K inhibitors in thrombosis and cardiovascular disease. Clinical and Translational Medicine, 9(1), 8.

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1. N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274): a potential novel PI3K inhibitor with low cardiotoxicity in mice;2024-02-29

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