Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) Toxicity-Reference-Cited by-同舟云学术

Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) Toxicity

Published:2009-05-27 Issue:12 Volume:52 Page:3742-3752
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hicks Latorya D.¹,Hyatt Janice L.¹,Stoddard Shana¹,Tsurkan Lyudmila¹,Edwards Carol C.¹,Wadkins Randy M.¹,Potter Philip M.¹

Affiliation:

1. Department of Molecular Pharmacology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105-2794, Department of Chemistry and Biochemistry, University of Mississippi, University, Mississippi 38677

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9001296

Reference44 articles.

1. Purification and Cloning of a Broad Substrate Specificity Human Liver Carboxylesterase That Catalyzes the Hydrolysis of Cocaine and Heroin

2. Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

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