Affiliation:
1. The Institute «Medical Academy named after S.I. Georgievsky» V.I. Vernadsky Crimean Federal University
2. OOO«Center of Clinical Oncology and Hematology»
Abstract
This article analyzes the statistical data on colorectal cancer in Russia and in the world, including incidence, mortality and survival. The main pathways of colorectal cancer carcinogenesis, molecular subtypes and their influence on the difference in lesions of the proximal and distal large intestine are presented. The paper provides an overview of the leading chemotherapy agents and targeted therapy in colorectal cancer, as well as the main reasons for the development of therapeutic resistance, including changes in the cellular microenvironment of the tumor.
Publisher
Russian Association of Coloproctology
Subject
Gastroenterology,Oncology,Surgery
Cited by
3 articles.
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