Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles-Reference-Cited by-同舟云学术

Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

Published:2014-12-12 Issue:24 Volume:57 Page:10486-10498
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aguilar Angelo¹,Sun Wei¹,Liu Liu¹,Lu Jianfeng¹,McEachern Donna¹,Bernard Denzil¹,Deschamps Jeffrey R.²,Wang Shaomeng¹

Affiliation:

1. University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine, Pharmacology, and Medicinal Chemistry, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109, United States

2. Naval Research Laboratory, Code 6930, 4555 Overlook Avenue, Washington, D.C. 20375, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501541j

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2. p53 in health and disease