Affiliation:
1. College of Pharmacy Guizhou University 550025 Guiyang Guizhou China
2. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education 550025 Guiyang China
3. Guizhou Engineering Laboratory for Synthetic Drugs Guizhou University 550025 Guiyang China
Abstract
AbstractP53 gene mutation is one of the important causes in tumors. p53‐MDM2 (murine double minute 2) inhibitors can interrupt p53‐dependent gene transcription activity, and inhibit p53‐mediated apoptosis, block p53‐MDM2/MDMx interaction, and significantly reduce DNA formation. In this article, we focused on the synthesis methods about nutlins and other p53 small molecule inhibitors, in order to find potential new structure for novel p53 small molecule inhibitor synthesizing.
Funder
Natural Science Foundation of Guizhou Province