Synthesis and SAR of Thrombin Inhibitors Incorporating a Novel 4-Amino-Morpholinone Scaffold: Analysis of X-ray Crystal Structure of Enzyme Inhibitor Complex-Reference-Cited by-同舟云学术

Synthesis and SAR of Thrombin Inhibitors Incorporating a Novel 4-Amino-Morpholinone Scaffold: Analysis of X-ray Crystal Structure of Enzyme Inhibitor Complex

Published:2003-08-13 Issue:19 Volume:46 Page:3985-4001
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nilsson Jonas W.¹,Kvarnström Ingemar¹,Musil Djordje¹,Nilsson Ingemar¹,Samulesson Bertil¹

Affiliation:

1. Department of Chemistry, Linköping University, S-581 83 Linköping, Sweden, AstraZeneca R&D, Structural Chemistry Laboratory, S-481 83 Mölndal, Sweden, Department of Organic Chemistry, Stockholm University, S-106 91 Stockholm, Sweden, Medivir AB, Lunastigen 7, S-141 44 Huddinge, Sweden, and AstraZeneca R&D, Medicinal Chemistry, S-431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0307990

Reference37 articles.

1. Antithrombotic agents

2. Non-covalent thrombin inhibitors featuring p 3 -heterocycles with P 1 -monocyclic arginine surrogates

3. Cardiovascular chemotherapy: anticoagulants

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