Affiliation:
1. School of Chemistry, Cardiff University
Abstract
Substituted morpholin-2-one derivatives were readily obtained in two steps starting from commercially available N-protected amino acids. In a metal-free and practical method, a catalytic amount of trifluoromethanesulfonic acid was sufficient to generate morpholinones under mild reaction conditions in an intramolecular hydroamination reaction in good to excellent yields.
Subject
Organic Chemistry,Catalysis
Cited by
3 articles.
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