Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities-Reference-Cited by-同舟云学术

Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities

Published:1999-07-22 Issue:16 Volume:42 Page:3018-3022
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bom David¹,Curran Dennis P.¹,Chavan Ashok J.¹,Kruszewski Stefan¹,Zimmer Stephen G.¹,Fraley Kimberly A.¹,Burke Thomas G.¹

Affiliation:

1. Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, Tigen Pharmaceuticals, Inc., Lexington, Kentucky 40506, and Division of Pharmaceutics Sciences, College of Pharmacy, Department of Microbiology and Immunology, College of Medicine, and Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40506

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9902279

Reference22 articles.

1. The Current Status of Camptothecin Analogues as Antitumor Agents

2. DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

3. A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

4. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

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