Affiliation:
1. Antibody Discovery and Protein Engineering, MedImmune, One MedImmune Way, Gaithersburg, MD 20878, United States
Abstract
DNA topoisomerases are enzymes that catalyze the alteration of DNA topology with transiently
induced DNA strand breakage, essential for DNA replication. Topoisomerases are validated
cancer chemotherapy targets. Anticancer agents targeting Topoisomerase I and II have been in clinical
use and proven to be highly effective, though with significant side effects. There are tremendous efforts
to develop new generation of topoisomerase inhibitors. Targeted delivery of topoisomerase inhibitors is
another way to reduce the side effects. Conjugates of topoisomerases inhibitors with antibody, polymer,
or small molecule are developed to target these inhibitors to tumor sites.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
35 articles.
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