Asymmetric Hydrogenation of Protected Allylic Amines-Reference-Cited by-同舟云学术

Asymmetric Hydrogenation of Protected Allylic Amines

Published:2010-08-24 Issue:18 Volume:12 Page:4201-4203
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Steinhuebel Dietrich P.¹,Krska Shane W.¹,Alorati Anthony¹,Baxter Jenny M.¹,Belyk Kevin¹,Bishop Brian¹,Palucki Michael¹,Sun Yongkui¹,Davies Ian W.¹

Affiliation:

1. Department of Process Research, Merck & Co. Inc., PO Box 2000, Rahway, New Jersey 07065, and Department of Process Research, Merck Sharp and Dohme Laboratories, Hertford Road, Hoddesdon, Hertfordshire EN11 9BU, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol101804e

Reference32 articles.

1. Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)

2. For the first synthesis, see:

3. Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache

4. Raney-Co Mediated Reductive Cyclization of an α,β-Unsaturated Nitrile

5. Unlocking the Potential of Asymmetric Hydrogenation at Merck

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