Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache
Author:
Affiliation:
1. Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol8011524
Reference15 articles.
1. New insights into the molecular actions of serotonergic antimigraine drugs
2. New therapeutic target in primary headaches – blocking the CGRP receptor
3. CGRP-Receptor Antagonists — A Fresh Approach to Migraine Therapy?
4. Calcitonin Gene–Related Peptide Receptor Antagonist BIBN 4096 BS for the Acute Treatment of Migraine
5. The CGRP-Antagonist, BIBN4096BS Does not Affect Cerebral or Systemic Haemodynamics in Healthy Volunteers
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