An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir-Reference-Cited by-同舟云学术

An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir

Published:2022-02-28 Issue:9 Volume:144 Page:3761-3765
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Burke Ashleigh J.¹,Birmingham William R.¹^ORCID,Zhuo Ying¹,Thorpe Thomas W.¹,Zucoloto da Costa Bruna¹,Crawshaw Rebecca¹,Rowles Ian¹,Finnigan James D.²,Young Carl²,Holgate Gregory M.³,Muldowney Mark P.³,Charnock Simon J.²,Lovelock Sarah L.¹^ORCID,Turner Nicholas J.¹^ORCID,Green Anthony P.¹^ORCID

Affiliation:

1. Department of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.

2. Prozomix Ltd, Building 4, West End Ind. Estate, Haltwhistle NE49 9HA, U.K.

3. Sterling Pharma Solutions, Sterling Place, Dudley, Northumberland NE23 7QG, U.K.

Funder

Engineering and Physical Sciences Research Council

UK Research and Innovation

Bill and Melinda Gates Foundation

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c11048

Reference20 articles.

1. Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

2. Painter, G. R.; Bluemling, G. R.; Natchus, M. G.; Guthrie, D. N4-hydroxycytidine and derivatives and anti-viral uses related thereto. WO2019113462, 2018.

3. A concise route to MK-4482 (EIDD-2801) from cytidine

4. Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

5. A High‐Yielding Synthesis of EIDD‐2801 from Uridine**

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