Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine-Reference-Cited by-同舟云学术

Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine

Published:2021-04-08 Issue:15 Volume:6 Page:10396-10402
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Ahlqvist Grace P.¹,McGeough Catherine P.¹,Senanayake Chris²,Armstrong Joseph D.²,Yadaw Ajay²,Roy Sarabindu²,Ahmad Saeed³,Snead David R.³^ORCID,Jamison Timothy F.¹^ORCID

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

2. TCG GreenChem, Inc., Process R&D Center at Princeton South, 701 Charles Ewing Boulevard, Ewing, New Jersey 08628, United States

3. Medicines for All Institute, 737 N. 5th Street, Box 980100, Richmond, Virginia 23298, United States

Funder

Division of Graduate Education

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsomega.1c00772

Reference12 articles.

1. Pfizer and BioNTech say their COVID-19 vaccine is successful in late-stage trial

2. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

3. Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

4. Painter, G. R.; Bluemling, G. R.; Natchus, M. G.; Guthrie, D. N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto. WO2019113462A12019

5. A concise route to MK-4482 (EIDD-2801) from cytidine

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