Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors-Reference-Cited by-同舟云学术

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors

Published:2020-05-15 Issue:23 Volume:142 Page:10358-10372
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

McAulay Kirsten¹,Hoyt Emily A.²^ORCID,Thomas Morgan¹,Schimpl Marianne³^ORCID,Bodnarchuk Michael S.¹^ORCID,Lewis Hilary J.¹^ORCID,Barratt Derek³,Bhavsar Deepa⁴,Robinson David M.¹,Deery Michael J.⁵,Ogg Derek J.³,Bernardes Gonçalo J. L.²⁶^ORCID,Ward Richard A.¹^ORCID,Waring Michael J.⁷^ORCID,Kettle Jason G.¹^ORCID

Affiliation:

1. Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

2. Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

3. Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB4 0WG, U.K.

4. Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States

5. Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, U.K.

6. Instituto de Medicina Molecular, Faculdade de Medicina de Universidad de Lisboa, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal

7. Northern Institute for Cancer Research, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.

Funder

AstraZeneca

Royal Society

Williams College

Cancer Research UK (Newcastle Drug Discovery Unit Programme Grant)

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.9b13391

Reference51 articles.