Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR-Reference-Cited by-同舟云学术

Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR

Published:2024-04-05 Issue:5 Volume:15 Page:583-589
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Pemberton Nils¹^ORCID,Compagne Nina¹,Argyrou Argyrides²^ORCID,Evertsson Emma¹,Gunnarsson Anders³,Kettle Jason G.⁴^ORCID,Orme Jonathan P.²,Ward Richard A.⁴^ORCID

Affiliation:

1. Medicinal Chemistry, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gothenburg 431 50, Sweden

2. Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom

3. Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 431 50, Sweden

4. Medicinal Chemistry, Oncology R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00425

Reference20 articles.

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3. The structure-guided discovery of osimertinib: the first U.S. FDA approved mutant selective inhibitor of EGFR T790M

4. Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies

5. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

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