Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On Probe-Reference-Cited by-同舟云学术

Construction of a Fluorescent Screening System of Allosteric Modulators for the GABAA Receptor Using a Turn-On Probe

Published:2019-08-16 Issue:9 Volume:5 Page:1541-1553
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Sakamoto Seiji¹^ORCID,Yamaura Kei¹,Numata Tomohiro²,Harada Fumio¹,Amaike Kazuma¹,Inoue Ryuji²,Kiyonaka Shigeki¹,Hamachi Itaru¹³^ORCID

Affiliation:

1. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan

2. Department of Physiology, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

3. ERATO Innovative Molecular Technology for Neuroscience Project, Japan Science and Technology Agency (JST), Kyoto 615-8530, Japan

Funder

Takeda Science Foundation

Daiichi Sankyo Foundation of Life Science

Exploratory Research for Advanced Technology

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acscentsci.9b00539

Reference54 articles.

1. Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

2. Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders

3. Harnessing Allostery: A Novel Approach to Drug Discovery

4. Detection of secondary binding sites in proteins using fragment screening

5. Identification of Regions of Rabbit Muscle Pyruvate Kinase Important for Allosteric Regulation by Phenylalanine, Detected by H/D Exchange Mass Spectrometry

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