Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists-Reference-Cited by-同舟云学术

Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists

Published:2020-10-26 Issue:11 Volume:6 Page:2008-2022
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Jacobson Max E.¹,Becker Kyle W.¹^ORCID,Palmer Christian R.¹^ORCID,Pastora Lucinda E.¹,Fletcher R. Brock²,Collins Kathryn A.¹,Fedorova Olga³,Duvall Craig L.²^ORCID,Pyle Anna M.³⁴^ORCID,Wilson John. T.¹²⁵⁶⁷^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States

2. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States

3. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06511, United States

4. Department of Chemistry, Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06511, United States

5. Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States

6. Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States

7. Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232, United States

Funder

Vanderbilt University

National Institute of Allergy and Infectious Diseases

Division of Graduate Education

Congressionally Directed Medical Research Programs

American Cancer Society

Alex's Lemonade Stand Foundation for Childhood Cancer

Division of Chemical, Bioengineering, Environmental, and Transport Systems

Division of Materials Research

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acscentsci.0c00568

Reference53 articles.

1. 5'-Triphosphate RNA Is the Ligand for RIG-I

2. 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

3. A minimal RNA ligand for potent RIG-I activation in living mice

4. Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

5. RIG-I activation is critical for responsiveness to checkpoint blockade

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