Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity-Reference-Cited by-同舟云学术

Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity

Published:2024 Issue:1 Volume:53 Page:317-360
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Zhang Heyang¹²,Vandesompele Jo³⁴,Braeckmans Kevin¹⁵^ORCID,De Smedt Stefaan C.¹⁴⁵,Remaut Katrien¹⁴^ORCID

Affiliation:

1. Laboratory for General Biochemistry and Physical Pharmacy, Department of Pharmaceutical Sciences, Ghent University, 9000 Ghent, Belgium

2. Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden, The Netherlands

3. Department of Biomolecular Medicine, Ghent University, 9000 Ghent, Belgium

4. Cancer Research Institute Ghent (CRIG), Ghent, Belgium

5. Centre for Nano- and Biophotonics, Ghent University, 9000 Ghent, Belgium

Abstract

This review discusses DNases and RNases present in the human body, strategies to reduce the degradation of gene therapeutics after administration and available methods to follow nuclease activity in buffer and living cells.

Funder

Fonds Wetenschappelijk Onderzoek

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CS/D3CS00194F

Reference467 articles.

1. Targeted protein degradation: A promise for undruggable proteins

2. Gene therapy returns to centre stage

3. Engineering circular RNA for enhanced protein production

4. The current landscape of nucleic acid therapeutics

5. Intracellular routing of plasmid DNA during non-viral gene transfer

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