A minimal RNA ligand for potent RIG-I activation in living mice-Reference-Cited by-同舟云学术

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A minimal RNA ligand for potent RIG-I activation in living mice

Published:2018-02-02 Issue:2 Volume:4 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Linehan Melissa M.¹^ORCID,Dickey Thayne H.²,Molinari Emanuela S.²,Fitzgerald Megan E.²,Potapova Olga²,Iwasaki Akiko¹²³^ORCID,Pyle Anna M.²³^ORCID

Affiliation:

1. Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

2. Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

3. Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.

Abstract

Short stem-loop RNAs activate RIG-I in mice, activating the innate immune system via specific patterns of gene expression.

Funder

Howard Hughes Medical Institute

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference72 articles.

1. RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity;Ramos H. J.;Curr. Opin. Virol.,2011

2. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

3. Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I;Devarkar S. C.;Proc. Natl. Acad. Sci. U.S.A.,2016

4. Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I;Weber M.;Cell Host Microbe,2015

5. Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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