A Route to Potent, Selective, and Biased Salvinorin Chemical Space-Reference-Cited by-同舟云学术

A Route to Potent, Selective, and Biased Salvinorin Chemical Space

Published:2023-07-12 Issue:8 Volume:9 Page:1567-1574
ISSN:2374-7943
Container-title:ACS Central Science
language:en
Short-container-title:ACS Cent. Sci.

Author:

Hill Sarah J.¹²,Dao Nathan¹²,Dang Vuong Q.³,Stahl Edward L.³,Bohn Laura M.³^ORCID,Shenvi Ryan A.¹²^ORCID

Affiliation:

1. Department of Chemistry, Scripps Research, La Jolla, California 92037, United States

2. Graduate School of Chemical and Biological Sciences, Scripps Research, La Jolla, California 92037, United States

3. Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida 33458, United States

Funder

National Institute on Drug Abuse

Natural Sciences and Engineering Research Council of Canada

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00616

Reference62 articles.

1. Natural products in drug discovery: advances and opportunities

2. Salvinorin A: A potent naturally occurring nonnitrogenous opioid selective agonist

3. The role of ligand efficiency metrics in drug discovery

4. Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans

5. A review of salvinorin analogs and their kappa-opioid receptor activity

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