Author:
Hopkins Andrew L.,Keserü György M.,Leeson Paul D.,Rees David C.,Reynolds Charles H.
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Reference86 articles.
1. Leeson, P. D. & Oprea, T. I. in Drug Design Strategies: Quantitative Approaches Ch. 2 (eds Livingstone, D. J. & Davis, A. M.) (Royal Society of Chemistry, 2012).
2. Gleeson, M. P., Hersey, A., Montanari, D. & Overington, J. Probing the links between in vitro potency, ADMET and physicochemical parameters. Nature Rev. Drug Discov. 10, 197–208 (2011).
3. Young, R. J., Green, D. V., Luscombe, C. N. & Hill, A. P. Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity. Drug Discov. Today 16, 822–830 (2011).
4. Waring, M. Defining optimum lipophilicity and molecular weight ranges for drug candidates —molecular weight dependent lower logD limits based on permeability. Bioorg. Med. Chem. Lett. 19, 2844–2851 (2009).
5. Johnson, T. W. et al. Using the golden triangle to optimize clearance and oral absorption. Bioorg. Med. Chem. Lett. 19, 5560–5564 (2009).
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