Natural Product Synthesis in the 21st Century: Beyond the Mountain Top

Author:

Shenvi Ryan A.12ORCID

Affiliation:

1. Department of Chemistry, Scripps Research, La Jolla, California 92037, United States

2. Graduate School of Chemical and Biological Sciences, Scripps Research, La Jolla, California 92037, United States

Funder

Division of Chemistry

National Center for Complementary and Integrative Health

National Institute on Drug Abuse

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Reference93 articles.

1. Race for Molecular Summits

2. NATO ASI Series E, Applied Sciences;Chryssostomos C.,2012

3. The idea that the field of natural product synthesis has contracted is based on grant review service, as well as a title and topic search for “total synthesis” in J. Am. Chem. Soc. from the United States. A single chemistry journal was chosen as representative because the total publication rate has increased worldwide, even among some individual journals, whereas the number of papers per year in J. Am. Chem. Soc. has remained steady for two decades. The United States was chosen as a representative country due to my personal interest in its science landscape, but also because U.S. publication rates in J. Am. Chem. Soc. have remained roughly consistent over three decades, while the rates in other countries have increased markedly. In the 1990s, there were ∼45 papers per year from the United States on the topic of total synthesis, and ∼70 on catalysis. By the late 2010s, these figures changed to ∼25 and ∼150, respectively.

4. Natural Product-likeness Score and Its Application for Prioritization of Compound Libraries

5. Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine

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2. Occurrence of “Natural Selection” in Successful Small Molecule Drug Discovery;Journal of Medicinal Chemistry;2024-07-01

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