Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib-Reference-Cited by-同舟云学术

Asymmetric Synthesis of Akt Kinase Inhibitor Ipatasertib

Published:2017-08-31 Issue:18 Volume:19 Page:4806-4809
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Han Chong^ORCID,Savage Scott,Al-Sayah Mohammad,Yajima Herbert,Remarchuk Travis,Reents Reinhard¹,Wirz Beat¹,Iding Hans¹,Bachmann Stephan¹,Fantasia Serena M.¹,Scalone Michelangelo¹,Hell André¹,Hidber Pirmin¹,Gosselin Francis^ORCID

Affiliation:

1. Department of Pharma Technical Development Small Molecules, F. Hoffmann-La Roche AG, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.7b02228

Reference22 articles.

1. The Akt/PKB pathway: molecular target for cancer drug discovery

2. AKT/PKB Signaling: Navigating Downstream

3. An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

4. Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

5. Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Development of Novel Pyridine and Pyrimidine Clubbed Bisindoles as Inhibitors of AKT Pathway;ChemistrySelect;2024-07-17

2. Excelzyme: A Swiss University-Industry Collaboration for Accelerated Biocatalyst Development;CHIMIA;2024-03-27

3. Biocatalyst Immobilization and Process Intensification: Production of (S)-Piperazine-2-carboxylic Acid Dihydrochloride;Organic Process Research & Development;2024-03-19

4. Effective engineering of a ketoreductase for the biocatalytic synthesis of an ipatasertib precursor;Communications Chemistry;2024-02-28

5. Industrial asymmetric biocatalysis;Biocatalysis in Asymmetric Synthesis;2024