Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate
Author:
Affiliation:
1. Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States
2. Genentech Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, California 94080-4990, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op500271w
Reference40 articles.
1. AKT signaling in normal and malignant cells
2. Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
3. Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor
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