Synthesis of 1,3-Aminoalcohols and Spirocyclic Azetidines via Tandem Hydroxymethylation and Aminomethylation Reaction of β-Keto Phosphonates with N-Nosyl-O-(2-bromoethyl)hydroxylamine
Author:
Affiliation:
1. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R. China
2. Analytical and Testing Center, Chongqing University, Chongqing 401331, China
Funder
Natural Science Foundation of Chongqing
National Natural Science Foundation of China
Venture & Innovation Support Program for Chongqing Overseas Returnees
the Fundamental Research Funds for Central Universities
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.1c01091
Reference38 articles.
1. aPalchykov, V. A.; Gaponov, A. A. In 1,3-Amino Alcohols and Their Phenol Analogs in Heterocyclization Reactions; Advances in Heterocyclic Chemistry; Scriven, E. F. V., Ramsden, C. A., Eds. Academic Press, 2020; Vol. 131, pp 285–350.
2. 1,3-Aminoalcohols and Their Derivatives in Asymmetric Organic Synthesis
3. Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
4. Synthesis of (S)-3-(N-Methylamino)-1-(2-thienyl)propan-1-ol: Revisiting Eli Lilly's Resolution−Racemization−Recycle Synthesis of Duloxetine for Its Robust Processes
5. Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters
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