Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy-Reference-Cited by-同舟云学术

Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy

Published:1998-01-22 Issue:4 Volume:41 Page:602-617
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kempf Dale J.¹,Sham Hing L.¹,Marsh Kennan C.¹,Flentge Charles A.¹,Betebenner David¹,Green Brian E.¹,McDonald Edith¹,Vasavanonda Sudthida¹,Saldivar Ayda¹,Wideburg Norman E.¹,Kati Warren M.¹,Ruiz Lisa¹,Zhao Chen¹,Fino LynnMarie¹,Patterson Jean¹,Molla Akhteruzzaman¹,Plattner Jacob J.¹,Norbeck Daniel W.¹

Affiliation:

1. Pharmaceutical Products Division, Abbott Laboratories, D-47D, AP52, 200 Abbott Park Road, Abbott Park, Illinois 60064

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970636%2B

Reference56 articles.

1. Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.

2. An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity.

3. HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins

4. Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1.

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