The Development of N-α-(2-Carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-α-(2-Carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors-Reference-Cited by-同舟云学术

The Development of N-α-(2-Carboxyl)benzoyl-N5-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-α-(2-Carboxyl)benzoyl-N5-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors

Published:2011-09-16 Issue:19 Volume:54 Page:6919-6935
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Causey Corey P.¹,Jones Justin E.²,Slack Jessica L.²,Kamei Daisuke³,Jones Larry E.¹,Subramanian Venkataraman²,Knuckley Bryan²,Ebrahimi Pedram⁴,Chumanevich Alexander A.⁴,Luo Yuan¹,Hashimoto Hiroshi³,Sato Mamoru³,Hofseth Lorne J.⁴,Thompson Paul R.²

Affiliation:

1. Department of Chemistry & Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, United States

2. Department of Chemistry, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States

3. Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

4. Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, 770 Sumter Street, Columbia, South Carolina 29208, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2008985

Reference55 articles.

1. Kinetic Characterization of Protein Arginine Deiminase 4: A Transcriptional Corepressor Implicated in the Onset and Progression of Rheumatoid Arthritis

2. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

3. Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3

4. Methylation of Arginine Residues Interferes with Citrullination by Peptidylarginine Deiminases in vitro

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