Machine-Directed Evolution of an Imine Reductase for Activity and Stereoselectivity-Reference-Cited by-同舟云学术

Machine-Directed Evolution of an Imine Reductase for Activity and Stereoselectivity

Published:2021-09-24 Issue:20 Volume:11 Page:12433-12445
ISSN:2155-5435
Container-title:ACS Catalysis
language:en
Short-container-title:ACS Catal.

Author:

Ma Eric J.¹,Siirola Elina²,Moore Charles²,Kummer Arkadij²,Stoeckli Markus³,Faller Michael⁴,Bouquet Caroline²,Eggimann Fabian²,Ligibel Mathieu²,Huynh Dan²,Cutler Geoffrey²,Siegrist Luca⁵,Lewis Richard A.²^ORCID,Acker Anne-Christine²,Freund Ernst²,Koch Elke⁴,Vogel Markus⁵,Schlingensiepen Holger⁴,Oakeley Edward J.⁴,Snajdrova Radka²^ORCID

Affiliation:

1. NIBR Informatics, Novartis Institutes for BioMedical Research (NIBR), 181 Massachusetts Ave, Cambridge, Massachusetts 02139, United States

2. Global Discovery Chemistry, Novartis Institutes for BioMedical Research (NIBR), Novartis Campus, CH-4056 Basel, Switzerland

3. Analytical Sciences and Imaging, Novartis Institutes for BioMedical Research (NIBR), Novartis Campus, CH-4056 Basel, Switzerland

4. Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research (NIBR), Novartis Campus, CH-4056 Basel, Switzerland

5. NIBR Biologics Center, Novartis Institutes for BioMedical Research (NIBR), Novartis Campus, CH-4056 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Catalysis,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acscatal.1c02786

Reference56 articles.

1. Biocatalysis

2. Biocatalysis: Enzymatic Synthesis for Industrial Applications

3. Computational redesign of enzymes for regio- and enantioselective hydroamination

4. Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59

5. Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design

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