Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design-Reference-Cited by-同舟云学术

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Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design

Published:2012-01 Issue:3 Volume:415 Page:615-625
ISSN:0022-2836
Container-title:Journal of Molecular Biology
language:en
Short-container-title:Journal of Molecular Biology

Author:

Wang Ling,Althoff Eric A.,Bolduc Jill,Jiang Lin,Moody James,Lassila Jonathan K.,Giger Lars,Hilvert Donald,Stoddard Barry,Baker David

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Howard Hughes Medical Institute

Defense Advanced Research Projects Agency

Publisher

Elsevier BV

Subject

Molecular Biology,Structural Biology

Reference34 articles.

1. De novo computational design of retro-aldol enzymes;Jiang;Science,2008

2. Kemp elimination catalysts by computational enzyme design;Rothlisberger;Nature,2008

3. Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis;List;Proc. Natl Acad. Sci. USA,1998

4. New algorithms and an in silico benchmark for computational enzyme design;Zanghellini;Protein Sci.,2006

5. Enzyme-like proteins by computational design;Bolon;Proc. Natl Acad. Sci. USA,2001

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