Structure-based Drug Discovery Using GPCR Homology Modeling: Successful Virtual Screening for Antagonists of the Alpha1A Adrenergic Receptor-Reference-Cited by-同舟云学术

Structure-based Drug Discovery Using GPCR Homology Modeling: Successful Virtual Screening for Antagonists of the Alpha1A Adrenergic Receptor

Published:2005-02-01 Issue:4 Volume:48 Page:1088-1097
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Evers Andreas¹,Klabunde Thomas¹

Affiliation:

1. Aventis Pharma Deutschland GmBH, Ein Unternehmen der Sanofi-Aventis Gruppe, DI&A Chemistry, Computational Chemistry, Industriepark Höchst, Building G838, D-65926 Frankfurt am Main, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0491804

Reference72 articles.

1. α1-Adrenoceptor subtypes

2. Identification of Nonpeptidic Urotensin II Receptor Antagonists by Virtual Screening Based on a Pharmacophore Model Derived from Structure−Activity Relationships and Nuclear Magnetic Resonance Studies on Urotensin II

3. Lead Generation Using Pharmacophore Mapping and Three-Dimensional Database Searching: Application to Muscarinic M3 Receptor Antagonists

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