1. Lead Generation Chemistry, Aventis Pharma Germany GmbH, Industriepark Hoechst, D-65926 Frankfurt am Main, Germany, Disease Group Cardiovascular, Aventis Pharma Germany GmbH, Industriepark Hoechst, D-65926 Frankfurt am Main, Germany, and Centre de Recherche en santé humaine, Institut Armand-Frappier, Université du Québec, Pointe-Claire, Quebec, Canada