Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB-Reference-Cited by-同舟云学术

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

Published:2009-11-12 Issue:1 Volume:53 Page:52-60
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mott Bryan T.¹,Ferreira Rafaela S.²³⁴,Simeonov Anton¹,Jadhav Ajit¹,Ang Kenny Kean-Hooi⁵,Leister William¹,Shen Min¹,Silveira Julia T.¹,Doyle Patricia S.⁴,Arkin Michelle R.⁵,McKerrow James H.⁴,Inglese James¹,Austin Christopher P.¹,Thomas Craig J.¹,Shoichet Brian K.²,Maloney David J.¹

Affiliation:

1. NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370 Bethesda, Maryland, 20892-3370

2. Department of Pharmaceutical Chemistry

3. Graduate Program in Chemistry and Chemical Biology

4. Sandler Center for Basic Research in Parasitic Diseases

5. Small Molecule Discovery Center

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901069a

Reference33 articles.

1. Chagas Disease;Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization:Geneva,http://www.who.int/tdr/diseases/chagas/direction.htm.

2. A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma brucei

3. Development of Potent Purine-Derived Nitrile Inhibitors of the Trypanosomal Protease TbcatB

4. A Cysteine Protease Inhibitor Protects Dogs from Cardiac Damage during Infection by Trypanosoma cruzi

5. Identification of a New Class of Nonpeptidic Inhibitors of Cruzain

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