Development of Potent Purine-Derived Nitrile Inhibitors of the Trypanosomal Protease TbcatB-Reference-Cited by-同舟云学术

Development of Potent Purine-Derived Nitrile Inhibitors of the Trypanosomal Protease TbcatB

Published:2008-01-04 Issue:3 Volume:51 Page:545-552
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mallari Jeremy P.¹,Shelat Anang A.¹,Obrien Terri¹,Caffrey Conor R.¹,Kosinski Aaron¹,Connelly Michele¹,Harbut Michael¹,Greenbaum Doron¹,McKerrow James H.¹,Guy R. Kiplin¹

Affiliation:

1. Graduate Program in Chemistry and Chemical Biology and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143-2280, Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis Tennessee 38105, and Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19146

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070760l

Reference34 articles.

1. A Cathepsin B-like Protease Is Required for Host Protein Degradation in Trypanosoma brucei

2. The phenomenon of treatment failures in Human African Trypanosomiasis

3. Risk factors for treatment failure after melarsoprol for Trypanosoma brucei gambiense trypanosomiasis in Uganda

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