A Cysteine Protease Inhibitor Protects Dogs from Cardiac Damage during Infection by Trypanosoma cruzi-Reference-Cited by-同舟云学术

A Cysteine Protease Inhibitor Protects Dogs from Cardiac Damage during Infection by Trypanosoma cruzi

Published:2005-12 Issue:12 Volume:49 Page:5160-5161
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barr S. C.¹,Warner K. L.¹,Kornreic B. G.¹,Piscitelli J.²,Wolfe A.³,Benet L.³,McKerrow J. H.⁴

Affiliation:

1. Department of Clinical Sciences, Cornell University School of Veterinary Medicine, Ithaca, New York 14850

2. Department of Clinical Pathology, Albert Einstein College of Medicine, Bronx, New York 10461

3. Department of Biopharmaceutical Science, University of California, San Francisco, California 94122

4. Department of Pathology, University of California, San Francisco, California 94122

Abstract

ABSTRACT Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi ; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi , as documented by histopathological lesion scores and serum troponin I levels.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.12.5160-5161.2005

Reference8 articles.

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2. Barr, S. C., V. A. Dennis, and T. R. Klei. 1991. Serological and blood culture survey of four dog populations for Trypanosoma cruzi from south Louisiana. Am. J. Vet. Res.52:570-573.

3. Barr, S. C., P. S. Schmidt, C. C. Brown, and T. R. Klei. 1991. Pathologic features of dogs inoculated with North American Trypanosoma cruzi isolates. Am. J. Vet. Res.52:2033-2039.

4. Barr, S. C., R. A. Holmes, and T. R. Klei. 1992. Electrocardiographic and echocardiographic features of trypanosomiasis in dogs inoculated with North American Trypanosoma cruzi isolates. Am. J. Vet. Res.53:521-527.

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