Pharmacokinetic Limitations to Overcome and Enable K777 as a Potential Drug against Chagas Disease
Author:
Affiliation:
1. Department of Pharmacy, Cesmac University Center, Maceió, Brazil
2. Department of Pharmacy, Postgraduate Program in Pharmaceutical Sciences, State University of Paraíba, Campina Grande, Brazil
Abstract
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology
Reference12 articles.
1. dos Santos Nascimento I.J.; de Aquino T.M.; da Silva-Júnior E.F.; Cruzain and rhodesain inhibitors: Last decade of advances in seeking for new compounds against American and African trypanosomiases. Curr Top Med Chem 2021,21(21),1871-1899
2. Mellott D.M.; Tseng C.T.; Drelich A.; A clinical-stage cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells. ACS Chem Biol 2021,16(4),642-650
3. Judice W.A.S.; Ferraz L.S.; Lopes R.M.; Cysteine proteases as potential targets for anti-trypanosomatid drug discovery. Bioorg Med Chem 2021,46,116365
4. Doyle P.S.; Zhou Y.M.; Engel J.C.; McKerrow J.H.; A cysteine protease inhibitor cures Chagas’ disease in an immunodeficient-mouse model of infection. Antimicrob Agents Chemother 2007,51(11),3932-3939
5. Barr S.C.; Warner K.L.; Kornreic B.G.; A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother 2005,49(12),5160-5161
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