A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells

Author:

Mellott Drake M.ORCID,Tseng Chien-Te1,Drelich Aleksandra1,Fajtová Pavla23,Chenna Bala C.ORCID,Kostomiris Demetrios H.,Hsu Jason1,Zhu Jiyun,Taylor Zane W.,Kocurek Klaudia I.,Tat Vivian1,Katzfuss Ardala,Li LinfengORCID,Giardini Miriam A.2,Skinner Danielle2,Hirata Ken2,Yoon Michael C.2,Beck Sungjun2,Carlin Aaron F.4,Clark Alex E.2,Beretta Laura2,Maneval Daniel,Hook Vivian2ORCID,Frueh Felix,Hurst Brett L.,Wang Hong,Raushel Frank M.ORCID,O’Donoghue Anthony J.2ORCID,de Siqueira-Neto Jair Lage2,Meek Thomas D.ORCID,McKerrow James H.2ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Texas, Medical Branch, 3000 University Boulevard, Galveston, Texas 77755-1001, United States

2. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093, United States

3. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 16610 Prague, Czech Republic

4. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California 92037, United States

Funder

National Institute of Allergy and Infectious Diseases

Burroughs Wellcome Fund

Selva Therapeutics, Inc.

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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