Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)-Reference-Cited by-同舟云学术

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

Published:2014-03-18 Issue:6 Volume:57 Page:2773-2788
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rackham Mark D.¹,Brannigan James A.²,Rangachari Kaveri³,Meister Stephan⁴,Wilkinson Anthony J.²,Holder Anthony A.³,Leatherbarrow Robin J.¹,Tate Edward W.¹

Affiliation:

1. Department of Chemistry, Imperial College London, London SW7 2AZ, U.K.

2. Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5DD, U.K.

3. MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, U.K.

4. Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California 92093, United States

Funder

Medical Research Council

Engineering and Physical Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500066b

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4. The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites

5. Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

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