Exploring Subsite Selectivity within <i>Plasmodium vivax</i> <i>N</i>-Myristoyltransferase Using Pyrazole-Derived Inhibitors-Reference-Cited by-同舟云学术

Exploring Subsite Selectivity within Plasmodium vivax N-Myristoyltransferase Using Pyrazole-Derived Inhibitors

Published:2024-04-29 Issue:9 Volume:67 Page:7312-7329
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rodríguez-Hernández Diego¹²,Fenwick Michael K.³⁴^ORCID,Zigweid Rachael³⁴,Sankaran Banumathi⁵,Myler Peter J.³⁴⁶,Sunnerhagen Per¹^ORCID,Kaushansky Alexis⁴⁶^ORCID,Staker Bart L.³⁴^ORCID,Grøtli Morten¹^ORCID

Affiliation:

1. Department of Chemistry and Molecular Biology, University of Gothenburg, S-405 30 Gothenburg, Sweden

2. Department of Structural and Functional Biology, Synthetic Biology Laboratory, Institute of Biology, University of Campinas, Campinas, SP 13083-862, Brazil

3. Seattle Structural Genomics Center for Infectious Disease, Seattle, Washington 98109, United States

4. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington 98109, United States

5. Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Advanced Light Source, Berkeley National Laboratory, Berkeley, California 94720, United States

6. Department of Pediatrics, University of Washington, Seattle, Washington 98195, United States

Funder

Vetenskapsrådet

National Institute of Allergy and Infectious Diseases

Swedish Foundation for International Cooperation in Research and Higher Education

U.S. Department of Health and Human Services

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00168

Reference58 articles.

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3. Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses

4. Relapses ofPlasmodium vivaxInfection Usually Result from Activation of Heterologous Hypnozoites

5. Host-targeted Interventions as an Exciting Opportunity to Combat Malaria