Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery-Reference-Cited by-同舟云学术

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

Published:2011-12-09 Issue:6061 Volume:334 Page:1372-1377
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Meister Stephan¹,Plouffe David M.²,Kuhen Kelli L.²,Bonamy Ghislain M. C.²,Wu Tao²,Barnes S. Whitney²,Bopp Selina E.¹,Borboa Rachel²,Bright A. Taylor¹³,Che Jianwei²,Cohen Steve²,Dharia Neekesh V.¹,Gagaring Kerstin²,Gettayacamin Montip⁴,Gordon Perry²,Groessl Todd²,Kato Nobutaka²,Lee Marcus C. S.⁵,McNamara Case W.²,Fidock David A.⁵⁶,Nagle Advait²,Nam Tae-gyu⁷,Richmond Wendy²,Roland Jason²,Rottmann Matthias⁸⁹,Zhou Bin²,Froissard Patrick¹⁰¹¹,Glynne Richard J.²,Mazier Dominique¹⁰¹¹¹²,Sattabongkot Jetsumon¹³,Schultz Peter G.⁷,Tuntland Tove²,Walker John R.²,Zhou Yingyao²,Chatterjee Arnab²,Diagana Thierry T.¹⁴,Winzeler Elizabeth A.¹²

Affiliation:

1. Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

2. Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.

3. Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, CA 92093, USA.

4. Department of Veterinary Medicine, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok 10400, Thailand.

5. Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

6. Department of Medicine (Division of Infectious Diseases), Columbia University Medical Center, New York, NY 10032, USA.

7. Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

8. Parasite Chemotherapy, Swiss Tropical and Public Health Institute, CH-4002 Basel, Switzerland.

9. University of Basel, CH-4003 Basel, Switzerland.

10. INSERM, U945, Paris, France.

11. Université Pierre et Marie Curie–Paris (UPMC), UMR S 945 Paris, France.

12. Assistance Publique–Hôpitaux de Paris, Groupe hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Paris, France.

13. Entomology Department, AFRIMS, Bangkok 10400, Thailand.

14. Novartis Institutes for Tropical Disease, Singapore.

Abstract

Imidazolopiperazine compounds inhibit liver-stage malaria parasites with one oral dose in mice.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

1. WHO World Malaria Report 2010. www.who.int/malaria/world_malaria_report_2010/en/index.html (2010).

2. A large focus of naturally acquired Plasmodium knowlesi infections in human beings

3. WHO Guidelines for the Treatment of Malaria www.who.int/malaria/publications/atoz/9789241547925/en/index.html (2011) p. 194.

4. SHORT REPORT: THE ACTIVITY OF PAMAQUINE, AN 8-AMINOQUINOLINE DRUG, AGAINST SPOROZOITE-INDUCED INFECTIONS OF PLASMODIUM VIVAX (NEW GUINEA STRAINS)

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