Identification of the Binding Modes of N-Phenylphthalimides Inhibiting Bacterial Thymidylate Synthase through X-Ray Crystallography Screening-Reference-Cited by-同舟云学术

Identification of the Binding Modes of N-Phenylphthalimides Inhibiting Bacterial Thymidylate Synthase through X-Ray Crystallography Screening

Published:2011-07-12 Issue:15 Volume:54 Page:5454-5467
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mangani Stefano¹,Cancian Laura²,Leone Rosalida¹,Pozzi Cecilia¹,Lazzari Sandra²,Luciani Rosaria²,Ferrari Stefania²,Costi M. Paola²

Affiliation:

1. Dipartimento di Chimica, Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy

2. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, 41126 Modena, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2005018

Reference34 articles.

1. THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

2. Thymidylate synthase inhibitors as anticancer agents: from bench to bedside

3. Structure-Based Discovery of Inhibitors of Thymidylate Synthase

4. Finer-Moore, J. S.; Blaney, J.; Stroud, R. M.,Computational and Structural Approaches to Drug Discovery;Stroud, R. M.; Finer-Moore, J. S., Eds;RSC:Cambridge, UK, 2008. p9.

5. Structure-Based Design of Inhibitors Specific for Bacterial Thymidylate Synthase,

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