Application of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine N-Methyltransferase: Balancing pKa and Steric Effects in the Optimization of 3-Methyl-1,2,3,4-tetrahydroisoquinoline Inhibitors by β-Fluorination-Reference-Cited by-同舟云学术

Application of the Goldilocks Effect to the Design of Potent and Selective Inhibitors of Phenylethanolamine N-Methyltransferase: Balancing pKa and Steric Effects in the Optimization of 3-Methyl-1,2,3,4-tetrahydroisoquinoline Inhibitors by β-Fluorination

Published:2006-04-14 Issue:10 Volume:49 Page:2939-2952
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Grunewald Gary L.¹,Seim Mitchell R.¹,Lu Jian¹,Makboul Mariam¹,Criscione Kevin R.¹

Affiliation:

1. Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm051262k

Reference59 articles.

1. Pharmacophore Features Distributions in Different Classes of Compounds

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