Halogen-bond-promoted direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoates with coumarins/quinolinones-Reference-Cited by-同舟云学术

Halogen-bond-promoted direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoates with coumarins/quinolinones

Published:2024 Issue:12 Volume:11 Page:3320-3325
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Pu Guoliang¹,Song Shi-Yuan²,Yang Jian¹,Guo Peng¹,Jia Jia¹,Liu Peijun¹,Li Xuefei¹³,Liu Ping²,He Chun-Yang¹⁴^ORCID

Affiliation:

1. Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, Zunyi Medical University, Zunyi, Guizhou, P. R. China

2. Key Laboratory of Clinical Pharmacy of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, China

3. Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, P. R. China

4. Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, P. R. China

Abstract

A practical method for the cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoates with coumarins/quinolinones was developed. The IC50 values of 3l against Huh-7 and A549 cells were determined to be 4.6 μM and 6.8 μM, respectively.

Funder

National Natural Science Foundation of China

Guizhou Science and Technology Department

Natural Science Foundation of Guizhou Province

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00484A

Reference42 articles.

1. 3,6-Disubstituted Coumarins as Mechanism-Based Inhibitors of Thrombin and Factor Xa

2. Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives

3. Novel coumarin aminophosphonates as potential multitargeting antibacterial agents against Staphylococcus aureus

4. Novel Coumarin Derivatives Inhibit the Quorum Sensing System and Iron Homeostasis as Antibacterial Synergists against Pseudomonas aeruginosa

5. Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design

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