Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design-Reference-Cited by-同舟云学术

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design

Published:2021-05-03 Issue:9 Volume:64 Page:6273-6299
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yan Nicholas L.¹,Santos-Martins Diogo²,Nair Reji¹^ORCID,Chu Alan³,Wilson Ian A.²,Johnson Kristen A.³,Forli Stefano²^ORCID,Morgan Gareth J.⁴⁵,Petrassi H. Michael³,Kelly Jeffery W.¹⁶^ORCID

Affiliation:

1. Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States

2. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States

3. California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, California 92037, United States

4. Section of Hematology and Medical Oncology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, United States

5. The Amyloidosis Center, Boston University School of Medicine, Boston, Massachusetts 02118, United States

6. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c00339