1. Bristol Medical School, University of Bristol, Bristol, BS8 1UD, UK
2. Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK
3. University Hospitals Bristol & Weston, NHS Foundation Trust, Bristol, BS1 3NU, UK
4. Institute of Cardiovascular Science, University College London, London, WC1E 6DD, UK
5. National Heart & Lung Institute, Imperial College London, London, SW3 6LY, UK